Stroke

    Overview

    Stroke is an abrupt interruption of constant blood flow to the brain that causes loss of neurological function. The interruption of blood flow can be caused by a blockage, leading to the more common ischemic stroke, or by bleeding in the brain, leading to the more deadly hemorrhagic stroke. Ischemic stroke constitutes an estimated 87 percent of all stroke cases. Stroke often occurs with little or no warning, and the results can be devastating.

    It is crucial that proper blood flow and oxygen be restored to the brain as soon as possible. Without oxygen and important nutrients, the affected brain cells are either damaged or die within a few minutes. Once brain cells die, they generally do not regenerate, and devastating damage may occur, sometimes resulting in physical, cognitive, and mental disabilities.

    Types

    There are two types of stroke.

    Ischemic Stroke 

    • Thrombotic (cerebral thrombosis) is the most common type of ischemic stroke. A blood clot forms inside a diseased or damaged artery in the brain resulting from atherosclerosis (cholesterol-containing deposits called plaque), blocking blood flow.
    • Embolic (cerebral embolism) is caused when a clot or a small piece of plaque formed in one of the arteries leading to the brain or in the heart, is pushed through the bloodstream and lodges in narrower brain arteries. The blood supply is cut off from the brain due to the clogged vessel.

    Hemorrhagic Stroke

    • Subarachnoid Hemorrhage: bleeding that occurs in the space between the surface of them brain and the skull. A common cause of subarachnoid hemorrhagic stroke is a ruptured cerebral aneurysm, an area where a blood vessel in the brain weakens, resulting in a bulging or ballooning out of part of the vessel wall; or the rupture of an arteriovenous malformation, a tangle of abnormal and poorly formed blood vessels (arteries and veins), with an innate propensity to bleed.
    • Intracerebral Hemorrhage: bleeding that occurs within the brain tissue. Many intracerebral hemorrhages are due to changes in the arteries caused by long-term hypertension. Other potential causes may be delineated through testing.

    Our providers

    Profiles

    Hesham Allam, MD

    Neurologist Neurology
    751 N. Rutledge St. Suite 3100 Springfield, IL 62702
    Profiles

    Nicole Atwood, AGACNP-BC

    Advance Practice Nurse
    751 N. Rutledge St. Suite 3100 Springfield, IL 62702
    Profiles

    Tosha Donnals, FNP-BC

    Family Nurse Practitioner Neurology
    Profiles

    Deidra Frisbie, FNP-C

    Certified Nurse Practitioner Neurology
    751 N. Rutledge St. Suite 3100 Springfield, IL 62702
    Profiles

    Carlos Illingworth Garcia, MD

    Neurocritical Care and Stroke specialist Neurology
    Profiles

    Breck Jones, MD

    Vascular, Endovascular, and Skull Base Neurosurgeon Neurosurgery
    747 N. Rutledge Street Suite 2204 Springfield, IL 62702
    Profiles

    Dale Korinek, Psy.D

    Clinical Neuropsychologist Psychiatry
    319 E Madison St 3rd Floor Springfield, IL 62702
    Profiles

    Lauri Lopp, MD

    Family Medicine
    520 N. 4th St. Springfield, IL 62702
    Profiles

    Paula Mackrides, DO

    Family Medicine
    612 N. 11th St. Quincy, IL 62301
    Profiles

    Sajjad Mueed, MD

    Director, Memorial Medical Center Stroke Center Neurology
    751 N. Rutledge St. Suite 3100 Springfield, IL 62702
    Profiles

    Khalil Qato, MD

    Vascular Surgeon Vascular Surgery
    Profiles

    William Robinson, MD

    Vascular Surgeon Vascular Surgery
    747 N. Rutledge Street 4th Floor Springfield, IL 62702
    Profiles

    Ankit Sharma, MD

    Family Medicine
    520 N. 4th St. Springfield, IL 62702

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    Clinical Trials

    Trial
    Neurology

    Portola: A Randomized Clinical Trial of Andexanet Alfa in Acute Intracranial Hemorrhage in Patients Receiving an Oral Factor XA Inhibitor

    Active not recruiting

    ANNEXa-1 (18-513): This is a randomized, multicenter clinical trial designed to determine the efficacy and safety of andexanet compared to usual care in patients presenting with acute intracerebral hemorrhage within 6 hours of symptom onset (from the baseline scan) and within 15 hours of taking an oral FXa inhibitor (from randomization). The study will use a prospective, randomized, open-label design, as it is unfeasible to blind the Investigator to the treatment assignment given the many potential therapeutic options available under usual care treatment.

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